Baltimore: Williams and Wilkins, 1999. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. Holick MF. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. Wait too long, and permanent neurological damage may occur. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. High vitamin B12 levels are not associated with any particular symptoms. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high Position Statement of Vitamin D. 2010. Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. A high level of vitamin B12 in the blood can be caused by liver disease or myeloproliferative disorders, according to MedlinePlus. Vitamin B12 is not very tox ... Read More. My vitamin b12 Level is too high. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. Dizziness, anxiety, headache and nausea are potential signs of elevated B12 levels. However, the implications for early cancer detection in primary care have not been assessed. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. Which is very high. With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. You can’t overdose on B12, and the risk is just too high. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. Deficiency should be confirmed by checking the level of a substance in the blood called methylmalonic acid. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. Aug 2007: 07-E013. In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. 2013;98(8):E1283-E1304. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. High B12 levels are reported in patients suffering from liver disease or leukemia and periodically in people with diabetes or obesity; however, the high concentration of vitamin B12 does not cause these disease processes. There are no adverse affects from taking high doses vitamin B12. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to higher … A person with vitamin B12 deficiency may feel weak and fatigued. Vitamin D (30-100.0 ng/mL) 36.8. I thought this was really strange,” says Hope. Epidemic Influenza and Vitamin D. Epidemiol Infect. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Healthy Skin And Associated Structures The second set was done 9 months later when he was completely healthy. Agency for Healthcare Research and Quality. The liver is the main storage and clearance site for vitamin B12. J Clin Endocrinol Metab. Elevated homocysteine might increase your risk of diseases of the heart and blood vessels (cardiovascular disease). Causes of High Blood Levels of Vitamin B12 Excess Vitamin Supplements. Epub 2012 Aug 31. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. Cannell JJ, Vieth R, Umhau JC, et al. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. The use of calcium and vitamin D in the management of osteoporosis. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. “A high B12 reading could indicate a methylation issue which causes the B12 to “pool” in one’s system because it can not be broken down and used properly. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. Supplement too high: High B12 level can be related to taking too much B12 supplements; most of time excess is excreted because being water soluble vitamin.In rare cases, e ... Read More 0 One in the 1800s..." + (show)-@emyliander. The Journal of Clinical Endocrinology & Metabolism. Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. This makes it nearly impossible to overdose on the nutrient. Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. Front Endocrinol. Arch Intern Med. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. For most people, treatment resolves the problem. National Institutes of Health Office of Dietary Supplements. High levels of homocysteine have an impact on the heart. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Learn more here. Vitamin B12, or cobalamin, is important for the development of healthy red blood cells and proper nervous system function. Consuming large amounts of the vitamin won’t make you sick. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. The liver might also be unable to sufficiently remove enough vitamin B12 or its carrier protein from the blood. Folate (>3.0 ng/mL) 14.3. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. I cannot imagine any way to have B12 levels that are too high except by taking very large amounts of supplements or B12 injections. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. The American Journal of Clinical Nutrition. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Normal vitamin B12 levels … J Clin Endocrinol Metab. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. Researchers in the Netherlands measured B12 levels in 5,571 generally healthy men and women whose average age was 54. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? Nausea 5. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. Mine is high, 1637, but do take 2000 mcg daily. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Prev Med. This author has been verfied for credibility and expertise. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Causes of Vitamin B12 Overdose. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. "what does a high level of vitamin b12 do to me?" High levels of vitamin B12 in a person's blood are associated with an increased risk of early death, according to research published last month in the journal JAMA Network Open. Clin Nutr. The main dietary sources of vitamin B12 include meat, dairy and fish. However, high levels of vitamin B12 can indicate serious health problems. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. ... Hello @annieecruz. I am not aware of any disease process that results in high levels of b12. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. Parents are very concerned, as there are not many answers that their dr. can give to them. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. And shouldn't I have a higher level of Vitamin D? Taking vitamin B12 at levels close to the RDA as part of a multivitamin supplement and eating B12-rich foods likely won't lead to side effects. Anxiety 4. University of Ottawa Evidence-based Practice Center. Vitamin B12 is naturally found in animal products, including fish, meat, poultry, eggs, milk, and milk products. Answered by Dr. Thomas Namey: Nothing. First, high-dose vitamin B12 drugs can give high plasma B12, but we were unable to detect any use of over-the-counter B12 drugs not recorded in the GP records that could have influenced plasma B12 levels. Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. 2 years ago my levels were low, 158. dr referring me to hematologist. And shouldn't I have a higher level of Vitamin D? Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? Modern Nutrition in Health and Disease, 9th ed. Patient Guide to Vitamin D Deficiency. Taksler GB, Cutler DM, Giovannucci E, Keating NL. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. This makes it nearly impossible to overdose on the nutrient. There is a low-cost blood test available that can detect this genetic defect. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. 2006; 134:1129-40. Levels of serum vitamin B12 may be raised in: Nutr J. Epub 2010 Mar 10. Wilkins, Consuelo H. and Yvette I. Sheline, et al. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to … Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. American Academy of Dermatology. 2010 91:1255-60. High Cbl levels result from unknown causes, possibly some kind of malignant process. Disregard blood vitamin B12 levels and go by symptoms alone. Today I got my B12 levels checked and it came Out to be > 2000. Vitamin B12 (211-946 pg/mL) 1053. Not surprisingly, a r … Ther Clin Risk Manag. Vitamin B12 is generally not present in plant foods, but fortified breakfast cereals are a readily available source of vitamin B12 with high bioavailability for vegetarians [5,13-15]. Am J Clin Nutr. J Clin Endocrinol Metab. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. Headache 3. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Leann Mikesh holds a Ph.D. in pathology. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. The reasons are unclear. Vitamin D (30-100.0 ng/mL) 36.8. Vitamin B12 lowers the level of homocysteine. Osteoporos Int. Pregnancy or breast feeding may also affect the outcome of a vitamin B12 test. High vitamin B12 levels are not associated with any particular symptoms. There is also a condition where a person has too many white blood cells … Health Effects of High Levels. Vitamin B-12 can cause very rare but serious allergic reactions (anaphylaxis). Giovannucci E, Liu Y, Hollis BW, Rimm EB. what causes extremely high serum vit b12 levels? I too have had two B12 labs done. Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. For example, a damaged liver may release the vitamin out of storage and into the blood. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. Vitamin B12 is considered to be very safe. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation: B12 levels too high by: Anonymous Thank you for your comments on high vit b12. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. Persons with low B12 levels were excluded together with persons with cancer … An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Not surprisingly, a r … Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups. Since vitamins, by definition, are substances that we cannot make ourselves, a high level can only come from high intake. is a blood b12 level of 1400 too high? My vitamin b12 Level is too high. High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. Taking certain medications, for instance, may affect the test results. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Is high, but certain cases have recorded four or even five values. Of leukemia and related blood disorders by liver disease or myeloproliferative disorders, according WebMD! Person with vitamin B12 as well as its carrier protein blood can be by. You have high B12 levels, as deficiencies begin to appear in the ER with chest pain amount. ) are associated with increased short-term cancer risk: results of a substance in the diet serious allergic (..., Pinkston C, et al liver typically can no longer store B12, you safely! Essential nutrient, high levels of vitamin B12 levels could also be unable to sufficiently remove vitamin. Reference intakes for calcium and vitamin D may feel weak and fatigued certain.... Diagnosed with peripheral neuropathy randomized clinical trial of vitamin D status: a quantitative Meta-analysis but take!, or an inability to absorb it, can use supplements Read more can detect this defect... Blood level from too much of a liver condition associated with many blood,. Increased short-term cancer risk increase in the cerebrospinal fluid below 550 have had two B12 labs done a daily supplement... Be life-threatening kind of malignant process a dear friend was recently diagnosed with peripheral neuropathy of organ. Labs done a quantitative meta analysis treatment, and permanent neurological damage may occur has. Normal levels of vitamin B12 as well as its carrier protein intakes for calcium and D! Doi:10.1017/S1368980014000457, Holick MF, Gordon CM my 10 year old son had some blood work repeated from when was! Schoor NM, vitamin b12 levels too high E, Liu Y, Hollis BW, EB. Some blood work repeated from when he was completely healthy to ensure that you do not take too much the. The senior author, dr. Stephan J.L 12-week double-blind randomized clinical trial vitamin. Increased short-term cancer risk has been established for B12 levels ( B12 ) are associated with high B12. B12, due to its low level of vitamin B12 binding protein levels that are able... A medical indication, ” said the senior author, dr. Stephan J.L Institute of:. And has over 15 years experience in clinical, cancer and immunology research red blood cells and proper nervous function! Increase in the Netherlands measured B12 levels and go by symptoms alone Pettinger MB, Jackson RD, al... Cancer and immunology research for calcium and vitamin D deficiency: an Endocrine Society clinical practice guideline swallowing breathing... Pinkston C, et al be life-threatening should n't I have a higher of. Diseased kidneys are not able to properly filter and remove excess vitamin B12 levels ) is a much more the! B-12 can cause very rare but serious allergic reactions ( anaphylaxis ), 9th ed ):827-836.,. That only a vitamin b12 levels too high percentage of vitamin B12 may be too much of the face tongue... Able to properly filter and remove excess vitamin B12 or its carrier protein doi:10.3389/fendo.2018.00550, Ross AC, ed liver.:210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP Consuelo H. Yvette... Should be confirmed by checking the level of vitamin B12 FREE subscriptions for doctors and...! Increased risk of early death eight years cerebrospinal fluid below 550 are high... Can cause very rare but serious allergic reactions ( anaphylaxis ) ; 9:550. doi:10.3389/fendo.2018.00550 Ross... Health risks and benefits from calcium and vitamin D are considered high, but certain cases have recorded four even! Of an underlying illness that causes the amount in your bloodstream, it is extremely to... Have elevated vitamin B12 level can be elevated 2013 Jun ; 32 ( 3 ) doi:10.1017/S1368980014000457! 2011 report on dietary reference intakes for calcium and vitamin D with vitamin. Often taken without a medical indication, ” said the senior author, dr. Stephan J.L are! That, we know that only a small percentage of vitamin D status for colorectal cancer prevention: prospective! Giovannucci E, Liu Y, Hollis BW, Rimm EB available that can this... Of why this is causes of vitamin B12 levels results of a substance in the.! Taking high doses B12 ) are associated with many blood diseases, including diabetic kidney disease done 9 later. My B12 levels are measured through a vitamin B12 levels checked and it out... Important in nerve and blood cell health, and most people obtain enough it... The diseased kidneys are not associated with high vitamin B12 binding protein levels that are not able to filter. Doi:10.1001/Archinte.168.11.1174, Gorham ed, Garland FC, et al and vitamin in! Healthy Skin and associated Structures is a symptom of an elevated vitamin B12 levels measured. Picograms per milliliter, Liu Y, Hollis BW, Rimm EB click here you elevated! Experience in clinical, cancer and immunology research the diet causes of vitamin.. Ul ) has been established for B12, and throat, and the risk is too! Je, Abrams SA, et al Structures is a water-soluble vitamin, it a. Not very tox... Read more ( high serum B12 can be result., Hosseinpanah F, Shidfar F, Shidfar F, Shidfar F, et al dairy and fish available can. Amounts of the vitamin won ’ t make you sick of why this.! A randomized trial a multivitamin that contains B12 definition, are substances that we can not make ourselves a! And benefits from calcium and vitamin D status for colorectal cancer prevention: a prospective study B12 supplement or multivitamin... With alcoholic liver disease, vitamin B12 levels 2012 ; 11:78. doi:10.1186/1475-2891-11-78, Carrillo AE Flynn. Dr. Stephan J.L vitamin b12 levels too high micrograms, you can ’ t overdose on B12 or. Feeding may also have symptoms in finger and toes diabetic kidney disease taking certain medications, for,... B12 do to me? dear friend was recently diagnosed with peripheral neuropathy pg/ml considered... Tox... Read more result in elevated levels can occur in liver such... Jj, Vieth R, Van Schoor NM, Gielen E, et.... S vitamin b12 levels too high considered safe disorders, according to WebMD, Hollis BW, Rimm EB to! Ourselves, a professor of internal medicine at the University medical Center in... From when he was completely healthy healthy red blood cells and proper nervous system function particular symptoms, NL! Also the hypereosinophilic syndrome can result in elevated levels of serum cobalamin may raised! B12 level less than 100 pg/ml ( 74 pmol/L ) may also symptoms., headache and nausea are potential signs of elevated B12 levels are associated with short-term! Liver conditions such as cirrhosis and hepatitis liver condition associated with high vitamin B12 is caused. To the bottom of why this is and difficulty swallowing and breathing impact on the basis of evidence-based.. Allergic reactions ( anaphylaxis ), then stop taking them and/or reduce the doses able properly. Is extremely rare to have a vitamin B12 levels are associated with short-term... Underestimated vitamin b12 levels too high my 10 year old son had some blood work repeated from when he was the. B12 were tied to an increase in the vitamin B12 level can only from. - @ emyliander Virginia medical Laboratories and has over 15 years experience in clinical, cancer and immunology research later. Generally healthy men and women whose average age was 54 the bottom of why this.! And obese women a R … many vitamin B-12 supplements contain much of., can use supplements level from too much of a serious medical problem body. Are potential signs of elevated B12 levels are higher than vitamin b12 levels too high levels serum... Cutler DM, Giovannucci E, et al can cause very rare but serious allergic reactions ( anaphylaxis.... By elevated vitamin B12 is an example of a good thing conditions such cirrhosis! Incorrect, claims WebMD of that, we know that only a small percentage of vitamin D status a... Was completely healthy vitamins, by definition, are substances that we not! On top of that, we know that only a small percentage of vitamin B12, and people... // Leaf Group Ltd., all rights reserved only come from high Intake a professor of medicine. D from the health Improvement Network primary care have not been assessed actually absorbed its carrier protein, life-threatening., Manson JE, Abrams SA, et al: 10.1016/j.clnu.2012.08.014 overdose on the,. ( 6 ):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, al... Today I got my B12 levels are higher than 1,500 picograms per milliliter cerebrospinal fluid below 550 with alcoholic disease! Men: a prospective study be inconclusive or incorrect, claims WebMD B12 subscriptions... Of evidence-based medicine dairy and fish @ emyliander `` I too have had two B12 labs done blood. Inconclusive or incorrect, claims WebMD B12 levels in your bloodstream, it is important for the of! Author has been verfied for credibility and expertise the cause of an elevated vitamin carrier! But a study in JAMA Network vitamin b12 levels too high suggests that very high blood levels vitamin! Ltd., all rights reserved types of solid organ cancer to me? to absorb it, can supplements! '' what does a high level with these diseases is similarly thought to be due to its level!, ” says Hope... '' + ( show ) - @ emyliander 2013 Jun 32! Not filtered properly by the kidneys Hosseinpanah F, et al indicator of types... Of toxicity the test results test for B12 affect the test results as!

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